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Bioengineering

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JoVE Journal Bioengineering
Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening
 

Automated Contraction Analysis of Human Engineered Heart Tissue for Cardiac Drug Safety Screening

Article DOI: 10.3791/55461-v • 10:39 min • April 15th, 2017
April 15th, 2017 •
1, 1, 1, 1, 1, 1, 1
1Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf and DZHK (German Center for Cardiovascular Research)

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요약
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Here, we show the generation of human engineered heart tissue from induced pluripotent stem cells (hiPSC)-derived cardiomyocytes. We present a method to analyze contraction force and exemplary alteration of contraction pattern by the hERG channel inhibitor E-4031. This method shows high level of robustness and suitability for cardiac drug screening.

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Automated Contraction Analysis Human Engineered Heart Tissue Cardiac Drug Safety Screening In Vitro Contraction Analysis Platform Drug Screening Disease Modeling Contractile Force Measurement Sterile Conditions Cellular Quality Medium Optimization Anika Benzin Umber Saleem Agarose Casting PDMS Racks Cardiomyocytes Concentration
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