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实验模型研究酸性后处理对脑缺血的神经保护作用
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Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
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实验模型研究酸性后处理对脑缺血的神经保护作用

DOI:
10.3791/55931-v

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10:13 min

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July 31, 2017

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, , , , , ,
1Institute of Pharmacology & Toxicology, College of Pharmaceutical Sciences, Department of Pharmacology, Key Laboratory of Medical Neurobiology of The Ministry of Health of China, Zhejiang Province Key Laboratory of Neurobiology,Zhejiang University

Chapters

  • 00:05Title
  • 00:57Cortical Slice Preparation
  • 02:43Oxygen-glucose Deprivation and Acidic Postconditioning
  • 04:03Determination of Slice Viability
  • 05:04Middle Cerebral Artery Occlusion
  • 07:22Reperfusion and Acidic Postconditioning
  • 08:16Results: Acidic Preconditioning Protects Against Reperfusion Injury
  • 09:32Conclusion

Summary

자동 번역

자동 번역

酸性后处理可防止脑缺血。在这里我们提出两个模型来执行APC。分别通过体外氧葡萄糖剥夺后将皮质硬膜下切片转移到酸性缓冲液中，并在体内大脑中动脉闭塞后吸入20％CO 2 。

Tags

NeuroprotectionAcidic PostconditioningCerebral IschemiaCortico Striatal Slice ModelMiddle Cerebral Artery Occlusion ModelIschemic Brain InjuryStroke TherapyAcidosis PostconditioningBrain Slice PreparationGlucose-free ACSFAcidic ACSFSynaptic Function Recovery

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