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1School of Biomedical Sciences & Curtin Health Innovation Research Institute,Curtin University, 2School of Public Health & Curtin Health Innovation Research Institute,Curtin University, 3Institute of Biochemistry,Christian-Albrechts-University, 4School of Veterinary and Life Sciences,Murdoch University, 5Centenary Institute of Cancer Medicine and Cell Biology,The University of Sydney, 6Royal Prince Alfred Hospital, 7A.W. Morrow Gastroenterology and Liver Centre, 8QIMR Berghofer Medical Research Institute, 9Faculty of Medicine and Biomedical Sciences,The University of Queensland, 10Fiona Stanley and Fremantle Hospitals, 11School of Medical and Health Sciences,Edith Cowan University, 12School of Medicine and Pharmacology,University of Western Australia
Chapters
- 00:00Title
- 01:21Choline-deficient and ethionine-supplemented diet treatment
- 02:27Liver perfusion and isolation
- 04:53Results: Representative CDE chronic liver injury model dynamics
- 06:51Conclusion
Nous décrivons ici une méthode commune pour induire des lésions chroniques du foie chez les souris en se nourrissant d’un régime alimentaire (CDE) déficients en choline et additionné d’éthionine. Nous démontrons la surveillance de la santé, perfusion hépatique, d’isolement et de préservation. Une durée de six semaines peut informer d’atteinte hépatique, pathohistology, fibrose, inflammation et les réponses des cellules progénitrices du foie.
