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自组装肽与氨基酸结合的水溶液中疏水性化合物的溶解度

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Solubility of Hydrophobic Compounds in Aqueous Solution Using Combinations of Self-assembling Peptide and Amino Acid

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自组装肽与氨基酸结合的水溶液中疏水性化合物的溶解度

DOI:

10.3791/56158-v

•

05:08 min

•

September 20, 2017

•

Shaun Pacheco, Shan-Yu Fung, Mingyao Liu³

¹Latner Thoracic Surgery Research Laboratories,University Health Network, ²Department of Pediatrics,British Columbia Children’s Hospital & University of British Columbia, ³Institute of Medical Science,University of Toronto

Chapters

00:05Title
00:37Preparation of Amino Acid Solutions
01:16Preparation of SAP-AA Solutions
01:56Preparation of Drug-DMSO or Drug-Ethanol Stock Solutions and Drug Formulations
03:11Solubility Testing
03:36Results: Enhancement of Hydrophobic Compound Solubility in Aqueous Solution with Self-assembling Peptide and Amino Acid Solutions
04:16Conclusion

Summary

자동 번역

本议定书描述了一种临床适用的方法, 溶解疏水化合物在水环境中使用自肽和氨基酸溶液的组合。我们的方法解决疏水疗法的一个主要局限, 缺乏安全, 有效的手段溶解和交付方法入临床设置。

Tags

Solubility Hydrophobic Compounds Aqueous Solution Self-assembling Peptide Amino Acid Drug Delivery Co-solvents DMSO Ethanol Formulation Vortex Sonication

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