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Journal / Genetics / 启动子捕获高分辨率,…
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Genetics

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JoVE Journal Genetics
启动子捕获高分辨率, 全基因组的启动子交互分析
 
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启动子捕获高分辨率, 全基因组的启动子交互分析

Article DOI: 10.3791/57320-v • 10:16 min • June 28th, 2018
June 28th, 2018 •
*1, *1,2, 1,3, 1,4, 1,5
1Nuclear Dynamics Programme, The Babraham Institute, Babraham Research Campus, 2IJC Building, Campus ICO-Germans Trias i Pujol, Josep Carreras Leukemia Research Institute, 3Departamento de Genética Molecular, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, 4Bioinformatics Group, The Babraham Institute, Babraham Research Campus, 5Department of Biological Science, Florida State University
* These authors contributed equally

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DNA 调控元素, 例如促进剂, 通过物理接触靶基因促进剂控制基因表达, 通常通过长距离染色体相互作用跨越大的基因组距离。启动子捕获高 c (PCHi) 确定促进者和远端区域之间的重要相互作用, 使潜在的调控序列分配给他们的目标基因。

Tags

遗传学 问题 136 3D 基因组组织 促进者 促进者 远距离相互作用 高 C cis调控元素 全基因组的协会研究 (GWAS) 非编码疾病变种 染色质循环 芝加哥 HiCUP
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