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1Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Lab, Division of Transplant, Department of Surgery, Comprehensive Transplant Center,Ohio State University Wexner Medical Center, 2Department of Surgery, Division of Transplant,Ohio State University Wexner Medical Center, 3Department of Surgery, Division of CardioThoracic Surgery,Ohio State University Wexner Medical Center, 4Department of Medicine,Ohio State University Wexner Medical Center
Chapters
- 00:04Title
- 00:36Preparation of the Portal Vein Cuff and Bile Duct Cannula
- 01:20Liver Procurement Procedure
- 05:24Ex Vivo Normothermic Liver Perfusion
- 06:58Results: Analysis of Tissue Damage in Base Perfusate-only and Base Perfusate and Plus PEG-CAT Groups
- 07:56Conclusion
There is a significant liver donor shortage, and criteria for liver donors have been expanded. Normothermic ex vivo liver perfusion (NEVLP) has been developed to evaluate and modify organ function. This study demonstrates a rat model of NEVLP and tests the ability of pegylated-catalase, to mitigate liver preservation injury.
