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Bioengineering

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JoVE Journal Bioengineering
Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation
 

Bioprintable Alginate/Gelatin Hydrogel 3D In Vitro Model Systems Induce Cell Spheroid Formation

Article DOI: 10.3791/57826-v • 16:20 min • July 2nd, 2018
July 2nd, 2018 •
*1, *2,3, 2, 4, 4, 3, 2,5
1Department of Mechanical Engineering, McGill University Montreal, 2Department of Bioengineering, McGill University Montreal, 3Department of Molecular Biology, Instituto Potosino de Investigación Científica y Tecnológica, A.C. (IPICyT), 4Department of Mining and Materials Engineering, McGill University Montreal, 5Department of Biomedical Engineering, McGill University Montreal
* These authors contributed equally

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요약
Automatic Translation

We developed a heterogeneous breast cancer model consisting of immortalized tumor and fibroblast cells embedded in a bioprintable alginate/gelatin bioink. The model recapitulates the in vivo tumor microenvironment and facilitates the formation of multicellular tumor spheroids, yielding insight into the mechanisms driving tumorigenesis.

Tags

Keywords: 3D In Vitro Model Bioprintable Hydrogel Alginate Gelatin Cell Spheroid Formation Cancer Biology Tumor Formation Cell Migration Cell Signaling Rheology Cell Compatibility Biosafety Centrifugation Rheometer
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