Waiting
로그인 처리 중...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Neuroscience / Generation and On-Demand Initiation of Acute…
JoVE Journal
Neuroscience

JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.

JoVE Journal Neuroscience
Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
 

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Article DOI: 10.3791/57952-v • 06:45 min • January 19th, 2019
January 19th, 2019 •
1,2, 1,3, 1,2,3,5,6, 1,2,3,4
1Division of Fundamental Neurobiology, Krembil Research Institute, 2Institute of Medical Science, Faculty of Medicine, University of Toronto, 3Institute of Biomaterials and Biomedical Engineering, University of Toronto, 4Division of Neurosurgery, Department of Surgery, University of Toronto, 5Division of Neurology, Department of Medicine, University of Toronto, 6Department of Physiology, University of Toronto

챕터

요약
Automatic Translation

Acute seizure models are important for studying the mechanisms underlying epileptiform events. Furthermore, the ability to generate epileptiform events on-demand provides a highly efficient method to study the exact sequence of events underlying their initiation. Here, we describe the acute 4-aminopyridine cortical seizure models established in mouse and human tissue.

Tags

Keywords: Acute Ictal Activity Seizure Mechanisms Electrographic Seizure Anti-seizure Therapies Cortical Slices Brain Tissue Vibratome Dissection Solution ACSF Incubation Chamber Electrophysiological Recordings
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter