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JoVE Journal Cancer Research
Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos
 

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos

Article DOI: 10.3791/58598-v • 07:24 min • December 13th, 2018
December 13th, 2018 •
*1,2, *1, 1
1Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 2Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School
* These authors contributed equally

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요약
Automatic Translation

This manuscript describes the synthesis of a single-wall carbon nanotube (SWCNT)-conjugated MALAT1 antisense gapmer DNA oligonucleotide (SWCNT-anti-MALAT1), which demonstrates the reliable delivery of the SWCNT and the potent therapeutic effect of anti-MALAT1 in vitro and in vivo. Methods used for synthesis, modification, conjugation, and injection of SWCNT-anti-MALAT1 are described.

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Keywords: Multiple Myeloma Single-wall Carbon Nanotube (SWCNT) MALAT1 Antisense Oligo Oligonucleotide Delivery In Vivo Nanoparticle Drug Delivery Treatment Centrifugal Filtration Sulfo-LC-SPDP Anti-MALAT1-Cy3 Mouse Model
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