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면역학 및 감염병학

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人正常记忆 b 细胞与长寿浆细胞体外分化模型

JoVE 신문
면역학 및 감염병학

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In Vitro Differentiation Model of Human Normal Memory B Cells to Long-lived Plasma Cells

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人正常记忆 b 细胞与长寿浆细胞体外分化模型

DOI:

10.3791/58929-v

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10:26 min

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January 20, 2019

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Michel Jourdan, Hugues de Boussac, Elena Viziteu, Alboukadel Kassambara, Jérôme Moreaux^2,3

¹IGH, CNRS,Univ Montpellier, ²Laboratory for Monitoring Innovative Therapies, Department of Biological Hematology,CHU Montpellier, ³UFR de Médecine,Univ Montpellier

Chapters

00:04Title
00:52B Cell Amplification and Differentiation
03:44Plasmablastic Cell Generation
04:36Early Plasma Cell Generation
05:21Long-lived Plasma Cell Generation
06:29Molecular Atlas of B to PC Differentiation
07:33Results: Epigenetic Factor Expression in Normal Plasma Cell Differentiation
09:01Conclusion

Summary

자동 번역

利用多步培养系统, 我们报告了体外 b 细胞对血浆细胞分化模型。

Tags

In Vitro Differentiation Human Normal Memory B Cells Long-lived Plasma Cells Plasma Cell Differentiation B2 Plasma Cell Differentiation Transcriptional Changes Phenotype Bioinformatic Tools Memory B Cell Purification CD40 Ligand Anti-polyhistidine Monoclonal Antibody

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