Waiting
로그인 처리 중...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Cancer Research / Important Endpoints and Proliferative Markers to…
JoVE Journal
Cancer Research

JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.

JoVE Journal Cancer Research
Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
 

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Article DOI: 10.3791/59236-v • 07:05 min • May 12th, 2019
May 12th, 2019 •
1, 1, 1,2
1Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 2Novo Nordisk Foundation Center of Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen

챕터

요약
Automatic Translation

Here, we present a protocol to establish important endpoints and proliferative markers of small intestinal injury and compensatory hyperproliferation using a model of chemotherapy-induced mucositis. We demonstrate the detection of proliferating cells using a cell cycle specific marker and using small intestinal weight, crypt depth, and villus height as endpoints.

Tags

Keywords: 5-Florauracil 5FU Chemotherapy-induced Mucositis Mouse Model Small Intestinal Injury Compensatory Hyperproliferation BrdU Quantification Histological Processing Image Analysis
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter