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Bioengineering

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JoVE Journal Bioengineering
Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate
 

Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

Article DOI: 10.3791/59399-v • 11:57 min • September 13th, 2019
September 13th, 2019 •
1, 2, 1,2,3
1Department of Medical Biophysics, Western University, 2Imaging Research Laboratory, Robarts Research Institute, Western University, 3Ontario Institute for Cancer Research

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요약
Automatic Translation

We present a protocol to measure the magnetic field dependence of the spin-lattice relaxation time of 13C-enriched compounds, hyperpolarized by means of dynamic nuclear polarization, using fast field-cycled relaxometry. Specifically, we have demonstrated this with [1-13C]pyruvate, but the protocol could be extended to other hyperpolarized substrates.

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Keywords: Hyperpolarized Spin-lattice Relaxation Magnetic Field Dependence DNP Pyruvate Polarization T1 MRI EDTA Dissolution Medium Microwave Sweep Optimal Frequency
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