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JoVE Journal Neuroscience
Targeting Alfa Synuclein aggregaten in cutane perifere zenuwvezels door Free-floating immunofluorescentie assay
 
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Targeting Alfa Synuclein aggregaten in cutane perifere zenuwvezels door Free-floating immunofluorescentie assay

Article DOI: 10.3791/59558-v • 08:33 min • June 25th, 2019
June 25th, 2019 •
1, 1, 1,2,3,4, 1,2
1Laboratory for Biomedical Neurosciences, Neurocenter of Southern Switzerland, 2Neurology Department, Neurocenter of Southern Switzerland, 3Department of Neurology, Inselspital, Bern University Hospital, University of Bern, 4Faculty of Biomedical Sciences, Università della Svizzera Italiana

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Hier presenteren we een protocol voor een vrij zwevende indirecte immunofluorescentie assay op de huid biopsie secties die het mogelijk maakt voor de identificatie van de ziekte specifieke conformatie varianten van Alfa synuclein betrokken bij de ziekte van Parkinson en meerdere eiwitten van de perifere zenuwstelsel.

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Neurowetenschappen kwestie 148 huid biopsie perifeer zenuwstelsel indirect immunofluorescentie vrij zwevend proteïne gen product 9,5 alpha-Synuclein phosphorylated alpha-Synuclein 5G4 eiwitcomplexen
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