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Genetics

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JoVE Journal Genetics
A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects (TEdefinitely) in Cancers
 
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A Murine Cell Line Based Model of Chronic CDK9 Inhibition to Study Widespread Non-Genetic Transcriptional Elongation Defects (TEdefinitely) in Cancers

Article DOI: 10.3791/59910-v • 10:49 min • September 26th, 2019
September 26th, 2019 •
1, 1, 1
1Division of Experimental Hematology and Cancer Biology, Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center (CCHMC)

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Das Protokoll beschreibt ein in vitro muriner Karzinommodell der nicht-genetischen defekten Transkriptionsdehnung. Hier wird die chronische Hemmung von CDK9 verwendet, um die produktive Dehnung von RNA Pol II entlang der pro-entzündlichen Reaktionsgene zu unterdrücken, um das klinisch überversorgteTE-Phänomen, das bei etwa 20% aller Krebsarten vorhanden ist, zu imitieren und zu untersuchen.

Tags

Genetik Ausgabe 151 Transkriptionsdehnung Tumorimmunologie CDK9 mRNA-Verarbeitung Flavopiridol RNA Pol II
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