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Journal / Developmental Biology / 通过转录因子的强制表达，人类纤维细胞的造血再编程…
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JoVE Journal Developmental Biology
通过转录因子的强制表达，人类纤维细胞的造血再编程
 
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通过转录因子的强制表达，人类纤维细胞的造血再编程

Article DOI: 10.3791/60112-v • 11:42 min • November 4th, 2019
November 4th, 2019 •
1,2,3, 3, 4, 5,6, 1,2,3
1Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, 2Wallenberg Center for Molecular, Lund University, 3Center for Neuroscience and Cell Biology, University of Coimbra, 4Skolkovo Institute of Science and Technology, 5Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 6Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai

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该协议通过强制表达转录因子GATA2、GFI1B和FOS来生成造血干细胞和祖细胞，证明在人类皮肤成纤维细胞中诱导造血程序。

Tags

发育生物学，第153期，造血再编程，成纤维细胞，转录因子，造血，造血干细胞和祖细胞，内皮到造血转化
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