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JoVE Journal
Cancer Research

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Kemisk-inducerad hud carcinogenes modell med Dimetylbenz [a] antracen och 12-O-Tetradecanoyl Phorbol-13-acetat (DMBA-TPA)
 
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Kemisk-inducerad hud carcinogenes modell med Dimetylbenz [a] antracen och 12-O-Tetradecanoyl Phorbol-13-acetat (DMBA-TPA)

Article DOI: 10.3791/60445-v 04:12 min December 19th, 2019
December 19th, 2019

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요약

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Två-stegs hud cancerogenesen induceras av två topikalt applicerade kemikalier. En mutagen 7, 12-dimetylbenz [a] antracen) orsakar mutationer i epidermala celler och en kontinuerlig tillämpning av allmän tillväxt stimulator 12-O-tetradecanoyl phorbol-13-acetat accelererar hudpapillom formation.

Tags

Cancer forskning hudcancer kemisk carcinogenes mutagen promotor DMBA-TPA papillom angiogenes inflammation tumör proliferation
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