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使用分体路西酶测定系统识别 HBx-DDB1 相互作用的抑制剂
 
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使用分体路西酶测定系统识别 HBx-DDB1 相互作用的抑制剂

Article DOI: 10.3791/60652-v • 05:55 min • December 21st, 2019
December 21st, 2019 •
1,2, 1, 1
1Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 2Research Fellow of Japan Society for the Promotion of Science

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요약
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在这里，我们提出了一种使用裂解荧光素酶检测系统来抑制HBx-DDB1相互作用的抗乙型肝炎病毒药物的方法。该系统易于检测蛋白质-蛋白质相互作用，适用于识别此类相互作用的抑制剂。

Tags

医学， 问题 154， 乙型肝炎病毒， 药物筛选， 高通量， 病毒-宿主相互作用， Smc5/6， 蛋白质-蛋白质相互作用， 硝基氮化物
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