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JoVE Journal Medicine
Panel LC-MS/MS validado para cuantificar 11 medicamentos resistentes a la tuberculosis en muestras de pelo pequeño
 
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Panel LC-MS/MS validado para cuantificar 11 medicamentos resistentes a la tuberculosis en muestras de pelo pequeño

Article DOI: 10.3791/60861-v • 08:54 min • May 19th, 2020
May 19th, 2020 •
1, 1, 1, 2, 3, 4, 1
1Department of Obstetrics, Gynecology and Reproductive Sciences, TB Hair Analysis Laboratory, University of California San Francisco, 2Department of Epidemiology and Biostatistics, University of California San Francisco, 3Department of Medicine, Division of HIV, Infectious Diseases, and Global Medicine, University of California San Francisco, 4Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of California San Francisco

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Los métodos actuales para analizar la adherencia de los pacientes a regímenes complejos de tuberculosis farmacorresistente (DR-TB) pueden ser inexactos e intensivos en recursos. Nuestro método analiza el cabello, una matriz fácilde de recoger y almacenar, para concentraciones de 11 medicamentos DR-TB. Usando LC-MS/MS, podemos determinar los niveles de fármacos subnanogramos que se pueden utilizar para entender mejor la adherencia a los medicamentos.

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Medicina Número 159 LC-MS/MS Medicamentos para la TB-MR Análisis capilar Monitoreo de adherencia Monitoreo terapéutico de fármacos TB resistente a los medicamentos
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