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Inducción de lesión cerebral axonal difusa en ratas basada en aceleración rotacional
JoVE 신문
신경과학
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JoVE 신문 신경과학
Induction of Diffuse Axonal Brain Injury in Rats Based on Rotational Acceleration
DOI:

06:14 min

May 09, 2020

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Chapters

  • 00:04Introduction
  • 00:45Preparing Rats for the Experimental Procedure
  • 01:11Procedure of Induction Diffuse Axonal Brain Injury
  • 01:54Measurement of Rotational Kinematics, Biomechanical Parameters
  • 02:32Evaluation of Neurological Severity Score after 48 hours
  • 03:08Brain Collection for Histological Examination after 48 hours
  • 04:02Immunohistochemical Staining
  • 04:16Results
  • 05:22Conclusion

Summary

자동 번역

Este protocolo valida un modelo de roedor fiable, fácil de realizar y reproducible de lesión axonal difusa cerebral (DAI) que induce daño generalizado a la materia blanca sin fracturas o contusiones de cráneo.

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