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Chapters
- 00:05Introduction
- 00:54First Experimental Animals and Mouse OIR Model Induction
- 01:59Drug Administration (Optional)
- 03:22Tissue Collection and Preparation of Retinal Flat Mounts
- 06:57Results: Rat and Mouse Models of OIR
- 08:39Conclusion
Oxygen-induced retinopathy (OIR) can be used to model ischemic retinal diseases such as retinopathy of prematurity and proliferative diabetic retinopathy and to serve as a model for proof-of-concept studies in evaluating antiangiogenic drugs for neovascular diseases. OIR induces robust and reproducible neovascularization in the retina that can be quantified.
