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用于细胞和药物输送应用的可注射超分子-纳米粒子水凝胶

JoVE 신문
생체공학

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JoVE 신문 생체공학

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

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用于细胞和药物输送应用的可注射超分子-纳米粒子水凝胶

DOI:

10.3791/62234-v

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09:39 min

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February 07, 2021

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Catherine M. Meis*¹, Abigail K. Grosskopf*², Santiago Correa, Eric A. Appel^3,4

¹Department of Materials Science & Engineering,Stanford University, ²Department of Chemical Engineering,Stanford University, ³Department of Bioengineering,Stanford University, ⁴Department of Pediatrics – Endocrinology,Stanford University

Chapters

00:04Introduction
00:49Nanoparticle (NP) Synthesis
02:10Hydrogel Formulation and Rheological Property Measurement
03:27In Vitro Drug Release Characterization
04:35Thermal Stability of Gel-Encapsulated Insulin Characterization
05:19Cell Viability Assessment
06:08Cell Settling Assessment
07:15Results: Representative Polymer Nanoparticle (PNP) Hydrogel Release Kinetics, Cargo Stability, and Cell Viability
09:00Conclusion

Summary

자동 번역

本协议描述了可注射超分子-纳米粒子（PNP）水凝胶生物材料的合成和配方。这些材料在药物输送、生物制药稳定、细胞封装和输送方面具有应用性。

Tags

Keywords: Injectable Supramolecular Polymer-nanoparticle Hydrogels Cell Delivery Drug Delivery Nano-precipitation PEG-PLA Dynamic Light Scattering HPMC-C12 Rheological Properties Drug Release

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