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Developmental Biology

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JoVE Journal Developmental Biology
A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
 

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis

Article DOI: 10.3791/62318-v • 08:06 min • March 19th, 2021
March 19th, 2021 •
*1, *1, 1
1Hubrecht Institute-KNAW (Royal Netherlands Academy of Arts and Sciences) and University Medical Center Utrecht
* These authors contributed equally

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요약
Automatic Translation

A protocol for the culture and manipulation of mouse embryonic tissue on a microfluidic chip is provided. By applying pulses of pathway modulators, this system can be used to externally control signaling oscillations for the functional investigation of mouse somitogenesis.

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Keywords: Microfluidics Signaling Oscillations Somitogenesis Signaling Dynamics PDMS Plasma Bonding Fibronectin Coating Mouse Embryos Functional Dissection
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