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建立胰腺癌斑马鱼患者来源的异种移植物进行化学敏感性测试
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Establishment of Zebrafish Patient-Derived Xenografts from Pancreatic Cancer for Chemosensitivity Testing
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建立胰腺癌斑马鱼患者来源的异种移植物进行化学敏感性测试

DOI:
10.3791/63744-v

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06:59 min

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May 12, 2023

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, , , ,
1Department of Biology,University of Pisa, 2General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery,University of Pisa

Chapters

  • 00:04Introduction
  • 00:56Sample Processing
  • 03:11Establishment of Zebrafish‐Based Patient‐Derived Xenografts (zPDX)
  • 04:56Treatment and Imaging
  • 05:40Results: Establishment of Zebrafish‐Based Patient‐Derived Xenografts (zPDXs) from Primary Human Pancreatic Adenocarcinoma
  • 06:14Conclusion

Summary

자동 번역

자동 번역

临床前模型旨在提高癌症生物学知识并预测治疗效果。本文描述了基于斑马鱼的患者来源的带有肿瘤组织碎片的异种移植物（zPDX）的产生。zPDXs用化疗治疗，根据移植组织的细胞凋亡评估其治疗效果。

Tags

ZebrafishPatient-derived XenograftPDXPancreatic CancerChemosensitivity TestingTumor MicroenvironmentPersonalized MedicineCell StainingXenograft Establishment

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