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JoVE Journal Neuroscience
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
 

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Article DOI: 10.3791/64014-v • 09:29 min • August 4th, 2022
August 4th, 2022 •
*1,2,3, *1, 1, 1
1Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 2Sidney Kimmel Medical College, Thomas Jefferson University, 3Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine
* These authors contributed equally

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요약
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The combination of laser capture microdissection and microfluidic RT-qPCR provides anatomic and biotechnical specificity in measuring the transcriptome in single neurons and glia. Applying creative methods with a system's biology approach to psychiatric disease may lead to breakthroughs in understanding and treatment such as the neuroinflammation antireward hypothesis in addiction.

Tags

Single-cell Gene Expression Anatomically Specific High Throughput Spatial Specificity Molecular Specificity QPCR Chip Microfluidic Mixing Device Prime Script PCR Sample Plate Reaction Assay Well Microfluidic RT-qPCR Platform Data Collection Software
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