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A Novel High-Throughput Ex Vivo Ovine Skin Wound Model for Testing Emerging Antibiotics
JoVE 비디오를 활용하시려면 도서관을 통한 기관 구독이 필요합니다. 전체 비디오를 보시려면 로그인하거나 무료 트라이얼을 시작하세요.
Chapters
- 00:05Introduction
- 00:53Sterilization and Preparation of the Head
- 03:06Maintenance of Skin Samples
- 04:18Infection of Skin Samples
- 05:27Determination of the Bacterial Load
- 06:32Results: An Ex Vivo Ovine Wounded Skin Model Infected with Staphylococcus aureus
- 07:42Conclusion
The protocol describes a step-by-step method to set up an ex vivo ovine wounded skin model infected with Staphylococcus aureus. This high-throughput model better simulates infections in vivo compared with conventional microbiology techniques and presents researchers with a physiologically relevant platform to test the efficacy of emerging antimicrobials.
