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Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
 

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Article DOI: 10.3791/64206-v 05:56 min October 13th, 2022
October 13th, 2022

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요약

The present protocol uses a biomolecular simulation package and describes the molecular dynamics (MD) approach for modeling the wild-type caspase and its mutant forms. The MD method allows for assessing the dynamic evolution of the caspase structure and the potential effect of mutations or post-translational modifications.

Tags

Keywords: Caspase Post-translational Modification Molecular Modeling Molecular Dynamics Protein Structure Cell Death Amber Energy Minimization Molecular Mechanics
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