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肠系膜上动脉闭塞的肠缺血再灌注损伤的啮齿动物模型

JoVE 신문
의학

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JoVE 신문 의학

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery

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肠系膜上动脉闭塞的肠缺血再灌注损伤的啮齿动物模型

DOI:

10.3791/64314-v

•

06:29 min

•

October 20, 2023

•

Lucie Henein², Randy Clevenger, Karen Keeran, Lauren Brinster

¹Animal Surgery and Resources Core, National Heart, Lung, and Blood Institute,National Institutes of Health, ²College of Veterinary Medicine,Mississippi State University, ³Division of Veterinary Resources, Office of Research Services,National Institutes of Health

Chapters

00:00Introduction
00:05Surgical Setup and Animal Preparation
01:29Surgery and Ischemia
03:56Tissue Collection and Processing for Histology
05:47Results: Post-IRI Analysis of Small Intestine

Summary

자동 번역

我们描述了如何生成啮齿动物肠缺血再灌注损伤（IRI）的广泛使用的手术模型。该手术包括闭塞肠系膜上动脉，然后恢复血流。该模型可用于调查兽医和人类医学中肠道 IRI 闭塞原因的研究。

Tags

Keywords: Rodent Model Intestinal Ischemia-reperfusion Injury Superior Mesenteric Artery Occlusion Anesthesia Buprenorphine Heparin Abdominal Incision Superior Mesenteric Artery Ischemia Reperfusion

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