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1Department of Anatomy, Cell Biology and Physiology,Indiana University School of Medicine, 2Department of Orthopaedic Surgery,Indiana University School of Medicine, 3Indiana Center for Musculoskeletal Health,Indiana University School of Medicine, 4School of Mechanical Engineering,Purdue University, 5Large Animal Resource Center,Indiana University School of Medicine, 6Department of Mechanical and Energy Engineering,Indiana University-Purdue University Indianapolis
Chapters
- 00:04Introduction
- 00:47Animal Preparation
- 01:49Surgical Exposure
- 03:36Impact of the Femoral Condyle
- 05:25Surgical Site Closure
- 06:23Results: Assessing Osteoarthritis Severity and Apoptotic Chondrocytes in the Impacted Medial Femoral Condyle
- 07:58Conclusion
Das offene mediale femorale Kondylus-Impaktmodell bei Kaninchen ist zuverlässig für die Untersuchung der posttraumatischen Osteoarthritis (PTOA) und neuer therapeutischer Strategien zur Eindämmung der PTOA-Progression. Dieses Protokoll erzeugt einen isolierten Knorpeldefekt des hinteren medialen Femurkondylus bei Kaninchen unter Verwendung eines schlittenbasierten Fallturms mit einem Impaktorkopf.
