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Cancer Research

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JoVE Journal Cancer Research
Intrakranial kanyleimplantasjon for serielle lokoregionale kimære antigenreseptor (CAR) T-celleinfusjoner hos mus
 
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Intrakranial kanyleimplantasjon for serielle lokoregionale kimære antigenreseptor (CAR) T-celleinfusjoner hos mus

Article DOI: 10.3791/64886-v • 05:22 min • February 24th, 2023
February 24th, 2023 •
1, 2,3, 2, 1,2, 1,2, 4,5, 2,3, 2,3, 1,2
1Division of Oncology, Children’s Hospital of Philadelphia, 2Center for Data Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia, 3Division of Neurosurgery, Children’s Hospital of Philadelphia, 4Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, 5Department of Pediatrics, Seattle Children’s Hospital, University of Washington

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Svulster i sentralnervesystemet (CNS) er den ledende årsaken til kreftrelatert død hos barn, og lokoregionale immunbaserte terapier blir i økende grad testet for pasienter i kliniske studier. Denne protokollen beskriver metoder for lokoregional kanyleimplantasjon hos mus for preklinisk evaluering av immunterapeutiske infusjoner rettet mot CNS-svulster.

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