Gary C. Sieck Department of Physiology and Biomedical Engineering Mayo Clinic Biography Publications Institution JoVE Articles Gary C. Sieck has not added a biography. If you are Gary C. Sieck and would like to personalize this page please email our Author Liaison for assistance. Publications β-adrenergic Stimulation After Rewarming Does Not Mitigate Hypothermia-induced Contractile Dysfunction in Rat Cardiomyocytes Cryobiology. Jun, 2024 | Pubmed ID: 38857777 Heterogeneous Distribution of Mitochondria and Succinate Dehydrogenase Activity in Human Airway Smooth Muscle Cells FASEB BioAdvances. Jun, 2024 | Pubmed ID: 38846375 Aging Related Decreases in NM Myosin Expression and Contractility in a Resistance Vessel Frontiers in Physiology. 2024 | Pubmed ID: 38808359 Postnatal Survival of Phrenic Motor Neurons is Promoted by BDNF/TrkB.FL Signaling Journal of Applied Physiology (Bethesda, Md. : 1985). May, 2024 | Pubmed ID: 38511211 Cervical Spinal Cord Hemisection Impacts Sigh and the Respiratory Reset in Male Rats Physiological Reports. Mar, 2024 | Pubmed ID: 38467570 Molecular Mechanisms Underlying TNFα-induced Mitochondrial Fragmentation in Human Airway Smooth Muscle Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2024 | Pubmed ID: 38084427 Sarcopenia of the Longitudinal Tongue Muscles in Rats Respiratory Physiology & Neurobiology. Jan, 2024 | Pubmed ID: 37863156 Chemical Chaperone 4-PBA Mitigates Tumor Necrosis Factor Alpha-Induced Endoplasmic Reticulum Stress in Human Airway Smooth Muscle International Journal of Molecular Sciences. Oct, 2023 | Pubmed ID: 37958799 Neuromotor Control of Spontaneous Quiet Breathing in Awake Rats Evaluated by Assessments of Diaphragm EMG Stationarity Journal of Neurophysiology. Nov, 2023 | Pubmed ID: 37877195 Chloroquine Impairs Maximal Transdiaphragmatic Pressure Generation in Old Mice Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2023 | Pubmed ID: 37823202 Cell-Based Measurement of Mitochondrial Function in Human Airway Smooth Muscle Cells International Journal of Molecular Sciences. Jul, 2023 | Pubmed ID: 37511264 Editorial: Towards an Understanding of Spinal and Corticospinal Pathways and Mechanisms Frontiers in Human Neuroscience. 2023 | Pubmed ID: 37025971 Size-dependent Differences in Mitochondrial Volume Density in Phrenic Motor Neurons Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2023 | Pubmed ID: 37022966 Molecular Mechanisms Underlying TNFα-Induced Mitochondrial Biogenesis in Human Airway Smooth Muscle International Journal of Molecular Sciences. Mar, 2023 | Pubmed ID: 36982859 Chemogenetic Inhibition of TrkB Signalling Reduces Phrenic Motor Neuron Survival and Size Molecular and Cellular Neurosciences. Jun, 2023 | Pubmed ID: 36958643 Electrophysiological Effects of BDNF and TrkB Signaling at Type-identified Diaphragm Neuromuscular Junctions Journal of Neurophysiology. Apr, 2023 | Pubmed ID: 36883761 Novel Regenerative Drug, SPG302 Promotes Functional Recovery of Diaphragm Muscle Activity After Cervical Spinal Cord Injury The Journal of Physiology. Jun, 2023 | Pubmed ID: 36815402 CTB-targeted Protocells Enhance Ability of Lanthionine Ketenamine Analogs to Induce Autophagy in Motor Neuron-like Cells Scientific Reports. Feb, 2023 | Pubmed ID: 36781993 Aging Affects the Number and Morphological Heterogeneity of Rat Phrenic Motor Neurons and Phrenic Motor Axons Physiological Reports. Jan, 2023 | Pubmed ID: 36695744 Brain Derived Neurotrophic Factor/tropomyosin Related Kinase B Signaling Impacts Diaphragm Neuromuscular Transmission in a Novel Rat Chemogenetic Model Frontiers in Cellular Neuroscience. 2022 | Pubmed ID: 36385943 Functional Recovery After Accidental Deep Hypothermic Cardiac Arrest: Comparison of Different Cardiopulmonary Bypass Rewarming Strategies Frontiers in Physiology. 2022 | Pubmed ID: 36134333 Structure and Function of the Mammalian Neuromuscular Junction Comprehensive Physiology. Aug, 2022 | Pubmed ID: 35950651 Autoregulation of Cerebral Blood Flow During 3-h Continuous Cardiopulmonary Resuscitation at 27°C Frontiers in Physiology. 2022 | Pubmed ID: 35755426 Mitochondrial Adaptations to Inactivity in Diaphragm Muscle Fibers Journal of Applied Physiology (Bethesda, Md. : 1985). Jul, 2022 | Pubmed ID: 35678745 Primary Cilia in Satellite Cells Are the Mechanical Sensors for Muscle Hypertrophy Proceedings of the National Academy of Sciences of the United States of America. Jun, 2022 | Pubmed ID: 35671424 Diaphragm Muscle Function in a Mouse Model of Early-onset Spasticity Journal of Applied Physiology (Bethesda, Md. : 1985). Jul, 2022 | Pubmed ID: 35608200 Enhanced Blood Clotting After Rewarming From Experimental Hypothermia in an Intact Porcine Model Frontiers in Physiology. 2022 | Pubmed ID: 35574436 Cooling to Hypothermic Circulatory Arrest by Immersion Vs. Cardiopulmonary Bypass (CPB): Worse Outcome After Rewarming in Immersion Cooled Pigs Frontiers in Physiology. 2022 | Pubmed ID: 35431978 CD38-NADase is a New Major Contributor to Duchenne Muscular Dystrophic Phenotype EMBO Molecular Medicine. May, 2022 | Pubmed ID: 35298089 Cervical Spinal Hemisection Alters Phrenic Motor Neuron Glutamatergic MRNA Receptor Expression Experimental Neurology. Jul, 2022 | Pubmed ID: 35247372 Automated Evaluation of Respiratory Signals to Provide Insight into Respiratory Drive Respiratory Physiology & Neurobiology. Jun, 2022 | Pubmed ID: 35218924 Physiological Impact of Hypothermia: The Good, the Bad, and the Ugly Physiology (Bethesda, Md.). Mar, 2022 | Pubmed ID: 34632808 Mitochondrial Morphology and Function Varies Across Diaphragm Muscle Fiber Types Respiratory Physiology & Neurobiology. Jan, 2022 | Pubmed ID: 34478909 Rat Model of Heart Failure With Preserved Ejection Fraction: Changes in Contractile Proteins Regulating Ca Cycling and Vascular Reactivity Circulation. Oct, 2021 | Pubmed ID: 34662164 Rewarming With Closed Thoracic Lavage Following 3-h CPR at 27°C Failed to Reestablish a Perfusing Rhythm Frontiers in Physiology. 2021 | Pubmed ID: 34658927 Mitochondrial Fragmentation and Dysfunction in Type IIx/IIb Diaphragm Muscle Fibers in 24-Month Old Fischer 344 Rats Frontiers in Physiology. 2021 | Pubmed ID: 34650442 Effects of Rewarming with Extracorporeal Membrane Oxygenation to Restore Oxygen Transport and Organ Blood Flow After Hypothermic Cardiac Arrest in a Porcine Model Scientific Reports. Sep, 2021 | Pubmed ID: 34556695 Cardiovascular Effects of Epinephrine During Experimental Hypothermia (32°C) With Spontaneous Circulation in an Intact Porcine Model Frontiers in Physiology. 2021 | Pubmed ID: 34552506 Effects of TNFα on Dynamic Cytosolic Ca and Force Responses to Muscarinic Stimulation in Airway Smooth Muscle Frontiers in Physiology. 2021 | Pubmed ID: 34393833 Tongue Muscle Contractile, Fatigue, and Fiber Type Properties in Rats Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2021 | Pubmed ID: 34323593 Physiology in Perspective: Eat, Sleep, Survive-Natural Cycle of Life Physiology (Bethesda, Md.). Jul, 2021 | Pubmed ID: 34159806 Reflections of an Outgoing Editor-in-Chief Physiology (Bethesda, Md.). Jul, 2021 | Pubmed ID: 34159802 Muscle-specific Deletion of the Vitamin D Receptor in Mice is Associated with Diaphragm Muscle Weakness Journal of Applied Physiology (Bethesda, Md. : 1985). Jul, 2021 | Pubmed ID: 34013750 Acute Intrathecal BDNF Enhances Functional Recovery After Cervical Spinal Cord Injury in Rats Journal of Neurophysiology. Jun, 2021 | Pubmed ID: 33949892 Dynamic Cytosolic Ca and Force Responses to Muscarinic Stimulation in Airway Smooth Muscle American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2021 | Pubmed ID: 33908264 Physiology in Perspective: Insulin-100 Years of Physiological Discovery Physiology (Bethesda, Md.). May, 2021 | Pubmed ID: 33904787 Maintaining Intravenous Volume Mitigates Hypothermia-induced Myocardial Dysfunction and Accumulation of Intracellular Ca Experimental Physiology. May, 2021 | Pubmed ID: 33728692 TrkB Signaling Contributes to Transdiaphragmatic Pressure Generation in Aged Mice Journal of Neurophysiology. Apr, 2021 | Pubmed ID: 33596726 Physiology in Perspective: Harnessing Homeostasis Physiology (Bethesda, Md.). Mar, 2021 | Pubmed ID: 33595383 Improving Gas Exchange and Exercise Tolerance in Mild COPD Patients The Journal of Physiology. Apr, 2021 | Pubmed ID: 33576012 Quantifying Mitochondrial Volume Density in Phrenic Motor Neurons Journal of Neuroscience Methods. Apr, 2021 | Pubmed ID: 33549636 Impact of Congenital Diaphragmatic Hernia on Diaphragm Muscle Function in Neonatal Rats Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2021 | Pubmed ID: 33507852 Diaphragm Neuromuscular Transmission Failure in a Mouse Model of an Early-onset Neuromotor Disorder Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2021 | Pubmed ID: 33382958 Physiology in Perspective: The Rhythm of Life-Circadian Patterns in Physiology Physiology (Bethesda, Md.). Jan, 2021 | Pubmed ID: 33325815 Age-related Impairment of Autophagy in Cervical Motor Neurons Experimental Gerontology. Feb, 2021 | Pubmed ID: 33290859 TNFα Induces Mitochondrial Fragmentation and Biogenesis in Human Airway Smooth Muscle American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2021 | Pubmed ID: 33146568 MOTOR NEURON LOSS IN AGING AND AMYOTROPHIC LATERAL SCLEROSIS: DIFFERENT FUSE LENGTHS, SAME EXPLOSION Physiological Mini-reviews. 2020 | Pubmed ID: 37577056 Growth and Survival Characteristics of Mice Animal Models and Experimental Medicine. Dec, 2020 | Pubmed ID: 33532707 Inflammation-Induced Protein Unfolding in Airway Smooth Muscle Triggers a Homeostatic Response in Mitochondria International Journal of Molecular Sciences. Dec, 2020 | Pubmed ID: 33396378 Why Individuals with Cerebral Palsy Are at Higher Risk for Respiratory Complications from COVID-19 Journal of Pediatric Rehabilitation Medicine. 2020 | Pubmed ID: 33136080 Physiology in Perspective: A Challenging Time Physiology (Bethesda, Md.). Nov, 2020 | Pubmed ID: 33095687 Extramyocellular Interleukin-6 Influences Skeletal Muscle Mitochondrial Physiology Through Canonical JAK/STAT Signaling Pathways FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2020 | Pubmed ID: 32885495 Cytoskeletal Remodeling Slows Cross-bridge Cycling and ATP Hydrolysis Rates in Airway Smooth Muscle Physiological Reports. Aug, 2020 | Pubmed ID: 32812390 Physiology in Perspective: A Key Role of Physiology in Understanding COVID-19 Physiology (Bethesda, Md.). Sep, 2020 | Pubmed ID: 32783611 Disproportionate Loss of Excitatory Inputs to Smaller Phrenic Motor Neurons Following Cervical Spinal Hemisection The Journal of Physiology. Oct, 2020 | Pubmed ID: 32735344 Physiology in Perspective: The New Normal-Life in a Pandemic Physiology (Bethesda, Md.). Jul, 2020 | Pubmed ID: 32490749 Study of the Effects of 3 H of Continuous Cardiopulmonary Resuscitation at 27°C on Global Oxygen Transport and Organ Blood Flow Frontiers in Physiology. 2020 | Pubmed ID: 32372965 Physiology in Perspective: In a World of Social Distancing Physiology (Bethesda, Md.). May, 2020 | Pubmed ID: 32293233 Impaired Neuromuscular Transmission of the Tibialis Anterior in a Rodent Model of Hypertonia Journal of Neurophysiology. May, 2020 | Pubmed ID: 32292122 Phrenic Motor Neuron Loss in an Animal Model of Early Onset Hypertonia Journal of Neurophysiology. May, 2020 | Pubmed ID: 32233911 Spinal Cord Injury and Diaphragm Neuromotor Control Expert Review of Respiratory Medicine. May, 2020 | Pubmed ID: 32077350 Physiology in Perspective: Physiological Systems Respond to Time Physiology (Bethesda, Md.). Mar, 2020 | Pubmed ID: 32024427 Inhibition of TrkB Kinase Activity Impairs Transdiaphragmatic Pressure Generation Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2020 | Pubmed ID: 31944892 TNFα Selectively Activates the IRE1α/XBP1 Endoplasmic Reticulum Stress Pathway in Human Airway Smooth Muscle Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2020 | Pubmed ID: 31940218 Diaphragm Muscle Sarcopenia into Very Old Age in Mice Physiological Reports. Jan, 2020 | Pubmed ID: 31908152 Physiology in Perspective: Complexity and Emergence of Function Physiology (Bethesda, Md.). Jan, 2020 | Pubmed ID: 31799906 Aging Reduces Succinate Dehydrogenase Activity in Rat Type IIx/IIb Diaphragm Muscle Fibers Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2020 | Pubmed ID: 31774353 Heterogeneous Glutamatergic Receptor MRNA Expression Across Phrenic Motor Neurons in Rats Journal of Neurochemistry. Jun, 2020 | Pubmed ID: 31563147 Diaphragm Muscle Adaptations in Health and Disease Drug Discovery Today. Disease Models. 2019 | Pubmed ID: 32863842 Endoplasmic Reticulum Stress and Mitochondrial Function in Airway Smooth Muscle Frontiers in Cell and Developmental Biology. 2019 | Pubmed ID: 32010691 Physiology in Perspective: Anatomy and Physiology-Structure and Function in Biology Physiology (Bethesda, Md.). Nov, 2019 | Pubmed ID: 31577167 Mechanisms Underlying TNFα-induced Enhancement of Force Generation in Airway Smooth Muscle Physiological Reports. Sep, 2019 | Pubmed ID: 31512410 Physiology in Perspective: Physiology Without Borders Physiology (Bethesda, Md.). Sep, 2019 | Pubmed ID: 31389774 Glutamatergic Input Varies with Phrenic Motor Neuron Size Journal of Neurophysiology. Oct, 2019 | Pubmed ID: 31389739 Cardiac Troponin-I Phosphorylation Underlies Myocardial Contractile Dysfunction Induced by Hypothermia Rewarming American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2019 | Pubmed ID: 31373512 Physiology in Perspective: The Dilemma of Muscle Weakness Physiology (Bethesda, Md.). Jul, 2019 | Pubmed ID: 31165686 Diaphragm Neuromuscular Transmission Failure in Aged Rats Journal of Neurophysiology. Jul, 2019 | Pubmed ID: 31042426 Physiology in Perspective: Physiology is Everywhere Physiology (Bethesda, Md.). May, 2019 | Pubmed ID: 30968752 A Critical Evaluation of Current Concepts in Cerebral Palsy Physiology (Bethesda, Md.). May, 2019 | Pubmed ID: 30968751 Impact of Sarcopenia on Diaphragm Muscle Fatigue Experimental Physiology. Jul, 2019 | Pubmed ID: 30924589 Evolution and Functional Differentiation of the Diaphragm Muscle of Mammals Comprehensive Physiology. Mar, 2019 | Pubmed ID: 30873594 Physiology in Perspective: Responding to a Changing Environment Physiology (Bethesda, Md.). Mar, 2019 | Pubmed ID: 30724131 Frequency-dependent Lipid Raft Uptake at Rat Diaphragm Muscle Axon Terminals Muscle & Nerve. May, 2019 | Pubmed ID: 30677149 Physiology in Perspective: Of Mice and Men Physiology (Bethesda, Md.). Jan, 2019 | Pubmed ID: 30540230 Hyperoxia-induced Cellular Senescence in Fetal Airway Smooth Muscle Cells American Journal of Respiratory Cell and Molecular Biology. Jul, 2019 | Pubmed ID: 30508396 Organ Blood Flow and O Transport During Hypothermia (27°C) and Rewarming in a Pig Model Experimental Physiology. Jan, 2019 | Pubmed ID: 30375081 Diaphragm Muscle Function Following Midcervical Contusion Injury in Rats Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2019 | Pubmed ID: 30236045 Phrenic Motoneuron Structural Plasticity Across Models of Diaphragm Muscle Paralysis The Journal of Comparative Neurology. Dec, 2018 | Pubmed ID: 30411341 Physiology in Perspective: Understanding the Aging Process Physiology (Bethesda, Md.). Nov, 2018 | Pubmed ID: 30303774 Physiology in Perspective: The Breath of Life Physiology (Bethesda, Md.). Sep, 2018 | Pubmed ID: 30109820 Impact of Aging on Diaphragm Muscle Function in Male and Female Fischer 344 Rats Physiological Reports. Jul, 2018 | Pubmed ID: 29981218 Physiology in Perspective: Physiology is Alive and Well Physiology (Bethesda, Md.). Jul, 2018 | Pubmed ID: 29897301 Differences in Lumbar Motor Neuron Pruning in an Animal Model of Early Onset Spasticity Journal of Neurophysiology. Aug, 2018 | Pubmed ID: 29718808 Impaired Autophagy in Motor Neurons: A Final Common Mechanism of Injury and Death Physiology (Bethesda, Md.). May, 2018 | Pubmed ID: 29638184 Physiology in Perspective: Seeking Solutions to Biological Questions Physiology (Bethesda, Md.). May, 2018 | Pubmed ID: 29616879 Role of Superoxide Ion Formation in Hypothermia/rewarming Induced Contractile Dysfunction in Cardiomyocytes Cryobiology. Apr, 2018 | Pubmed ID: 29458041 Phrenic Motor Neuron Loss in Aged Rats Journal of Neurophysiology. May, 2018 | Pubmed ID: 29412773 Physiology in Perspective: Homeostasis and Survival Physiology (Bethesda, Md.). Mar, 2018 | Pubmed ID: 29412060 Breathing: Motor Control of Diaphragm Muscle Physiology (Bethesda, Md.). Mar, 2018 | Pubmed ID: 29412056 Quantifying Effect of Onabotulinum Toxin A on Passive Muscle Stiffness in Children with Cerebral Palsy Using Ultrasound Shear Wave Elastography American Journal of Physical Medicine & Rehabilitation. Jul, 2018 | Pubmed ID: 29406405 1α,25-dihydroxyvitamin D Mitigates Cancer Cell Mediated Mitochondrial Dysfunction in Human Skeletal Muscle Cells Biochemical and Biophysical Research Communications. Feb, 2018 | Pubmed ID: 29366785 Diaphragm Muscle Activity Across Respiratory Motor Behaviors in Awake and Lightly Anesthetized Rats Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2018 | Pubmed ID: 29357493 Uptake and Intracellular Fate of Cholera Toxin Subunit B-modified Mesoporous Silica Nanoparticle-supported Lipid Bilayers (aka Protocells) in Motoneurons Nanomedicine : Nanotechnology, Biology, and Medicine. Apr, 2018 | Pubmed ID: 29339186 Physiology in Perspective: Stem Cells and Regenerative Physiology Physiology (Bethesda, Md.). Jan, 2018 | Pubmed ID: 29212888 Physiology in Perspective: Physiology Provides Insight into Health Physiology (Bethesda, Md.). Nov, 2017 | Pubmed ID: 29021360 Physiology in Perspective: The Value of Integrative Physiology Physiology (Bethesda, Md.). Sep, 2017 | Pubmed ID: 28794214 Compensatory Effects Following Unilateral Diaphragm Paralysis Respiratory Physiology & Neurobiology. Dec, 2017 | Pubmed ID: 28790008 Impact of Glutamatergic and Serotonergic Neurotransmission on Diaphragm Muscle Activity After Cervical Spinal Hemisection Journal of Neurophysiology. Sep, 2017 | Pubmed ID: 28659464 Physiology in Perspective: Structure and Function-Anatomy and Physiology Are Integral Physiology (Bethesda, Md.). Jul, 2017 | Pubmed ID: 28615310 TNFα Decreases Mitochondrial Movement in Human Airway Smooth Muscle American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2017 | Pubmed ID: 28473328 Physiology in Perspective: The Importance of Integrative Physiology Physiology (Bethesda, Md.). May, 2017 | Pubmed ID: 28404734 TNFα Enhances Force Generation in Airway Smooth Muscle American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2017 | Pubmed ID: 28385814 Mitochondrial Dysfunction in Airway Disease Chest. Sep, 2017 | Pubmed ID: 28336486 Physiology in Perspective: Homeostasis and Evolution Physiology (Bethesda, Md.). Mar, 2017 | Pubmed ID: 28202620 Chronic TrkB Agonist Treatment in Old Age Does Not Mitigate Diaphragm Neuromuscular Dysfunction Physiological Reports. Jan, 2017 | Pubmed ID: 28082429 Physiology in Perspective: Aging and Underlying Pathophysiology Physiology (Bethesda, Md.). Jan, 2017 | Pubmed ID: 27927800 Diaphragm Electromyographic Activity Following Unilateral Midcervical Contusion Injury in Rats Journal of Neurophysiology. Feb, 2017 | Pubmed ID: 27832610 BDNF Effects on Functional Recovery Across Motor Behaviors After Cervical Spinal Cord Injury Journal of Neurophysiology. Feb, 2017 | Pubmed ID: 27832605 Motoneuron Glutamatergic Receptor Expression Following Recovery from Cervical Spinal Hemisection The Journal of Comparative Neurology. Apr, 2017 | Pubmed ID: 27650492 Functional Effects of Cigarette Smoke-Induced Changes in Airway Smooth Muscle Mitochondrial Morphology Journal of Cellular Physiology. May, 2017 | Pubmed ID: 27474898 A Novel Approach for Targeted Delivery to Motoneurons Using Cholera Toxin-B Modified Protocells Journal of Neuroscience Methods. Nov, 2016 | Pubmed ID: 27641118 Functional Measurement of Respiratory Muscle Motor Behaviors Using Transdiaphragmatic Pressure Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27492181 Quantifying Passive Muscle Stiffness in Children with and Without Cerebral Palsy Using Ultrasound Shear Wave Elastography Developmental Medicine and Child Neurology. Dec, 2016 | Pubmed ID: 27374483 Aging-related Changes in Respiratory System Mechanics and Morphometry in Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2016 | Pubmed ID: 27288490 Physiology in Perspective: Physiological Transitions During Our Lifespan Physiology (Bethesda, Md.). Jul, 2016 | Pubmed ID: 27252159 Diaphragm Muscle Sarcopenia in Fischer 344 and Brown Norway Rats Experimental Physiology. Jul, 2016 | Pubmed ID: 27126607 Physiology in Perspective: Sensing Our Environment Triggers Physiological and Evolutionary Adaptation Physiology (Bethesda, Md.). May, 2016 | Pubmed ID: 27053730 Hypothermia/rewarming Disrupts Excitation-contraction Coupling in Cardiomyocytes American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2016 | Pubmed ID: 26993227 Physiology in Perspective: Pursuing the Enchanted Loom of Motor Control Physiology (Bethesda, Md.). Mar, 2016 | Pubmed ID: 26865576 Analysis of Fluid Movement in Skeletal Muscle Using Fluorescent Microspheres Muscle & Nerve. Sep, 2016 | Pubmed ID: 26833456 Physiology in Perspective: Fulfilling the Promise of Tissue Engineering Physiology (Bethesda, Md.). Jan, 2016 | Pubmed ID: 26661523 TrkB Gene Therapy by Adeno-associated Virus Enhances Recovery After Cervical Spinal Cord Injury Experimental Neurology. Feb, 2016 | Pubmed ID: 26607912 1α,25-Dihydroxyvitamin D3 Regulates Mitochondrial Oxygen Consumption and Dynamics in Human Skeletal Muscle Cells The Journal of Biological Chemistry. Jan, 2016 | Pubmed ID: 26601949 Effects of Antenatal Lipopolysaccharide and Postnatal Hyperoxia on Airway Reactivity and Remodeling in a Neonatal Mouse Model Pediatric Research. Mar, 2016 | Pubmed ID: 26539665 Functional Recovery After Cervical Spinal Cord Injury: Role of Neurotrophin and Glutamatergic Signaling in Phrenic Motoneurons Respiratory Physiology & Neurobiology. Jun, 2016 | Pubmed ID: 26506253 Functional Impact of Sarcopenia in Respiratory Muscles Respiratory Physiology & Neurobiology. Jun, 2016 | Pubmed ID: 26467183 The Impact of Midcervical Contusion Injury on Diaphragm Muscle Function Journal of Neurotrauma. Mar, 2016 | Pubmed ID: 26413840 Physiology in Perspective: Why Do We Continue to Ignore Sex Differences? Physiology (Bethesda, Md.). Nov, 2015 | Pubmed ID: 26525339 Role of TrkB Kinase Activity in Aging Diaphragm Neuromuscular Junctions Experimental Gerontology. Dec, 2015 | Pubmed ID: 26517952 Physiology in Perspective: The Air We Breathe: Providing O2 for Survival Physiology (Bethesda, Md.). Sep, 2015 | Pubmed ID: 26328878 Semi-automated Assessment of Transdiaphragmatic Pressure Variability Across Motor Behaviors Respiratory Physiology & Neurobiology. Aug, 2015 | Pubmed ID: 26003850 Muscle Weakness in Critical Illness American Journal of Respiratory and Critical Care Medicine. May, 2015 | Pubmed ID: 25978566 Functional Impact of Diaphragm Muscle Sarcopenia in Both Male and Female Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2015 | Pubmed ID: 25934669 Analysis of Muscle Fiber Clustering in the Diaphragm Muscle of Sarcopenic Mice Muscle & Nerve. Jul, 2015 | Pubmed ID: 25808550 Feasibility and Reliability of Quantifying Passive Muscle Stiffness in Young Children by Using Shear Wave Ultrasound Elastography Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine. Apr, 2015 | Pubmed ID: 25792582 Impact of Unilateral Denervation on Transdiaphragmatic Pressure Respiratory Physiology & Neurobiology. May, 2015 | Pubmed ID: 25641347 Ageing and Neurotrophic Signalling Effects on Diaphragm Neuromuscular Function The Journal of Physiology. Jan, 2015 | Pubmed ID: 25630263 Interaction Between Endoplasmic/sarcoplasmic Reticulum Stress (ER/SR Stress), Mitochondrial Signaling and Ca(2+) Regulation in Airway Smooth Muscle (ASM) Canadian Journal of Physiology and Pharmacology. Feb, 2015 | Pubmed ID: 25506723 Localized Delivery of Brain-derived Neurotrophic Factor-expressing Mesenchymal Stem Cells Enhances Functional Recovery Following Cervical Spinal Cord Injury Journal of Neurotrauma. Feb, 2015 | Pubmed ID: 25093762 Cardiovascular Effects of Levosimendan During Rewarming from Hypothermia in Rat Cryobiology. Dec, 2014 | Pubmed ID: 25280932 Recruitment of Rat Diaphragm Motor Units Across Motor Behaviors with Different Levels of Diaphragm Activation Journal of Applied Physiology (Bethesda, Md. : 1985). Dec, 2014 | Pubmed ID: 25257864 Paradoxical Use of Tumor Necrosis Factor in Treating Pulmonary Edema American Journal of Respiratory and Critical Care Medicine. Sep, 2014 | Pubmed ID: 25221873 Positive End-expiratory Airway Pressure Does Not Aggravate Ventilator-induced Diaphragmatic Dysfunction in Rabbits Critical Care (London, England). Sep, 2014 | Pubmed ID: 25212227 TrkB Kinase Activity Maintains Synaptic Function and Structural Integrity at Adult Neuromuscular Junctions Journal of Applied Physiology (Bethesda, Md. : 1985). Oct, 2014 | Pubmed ID: 25170066 Response to Letter by Dr. Marc Hershenson (exposure of Airway Smooth Muscle Cells to Cigarette Smoke Extract) American Journal of Physiology. Lung Cellular and Molecular Physiology. Aug, 2014 | Pubmed ID: 25128539 TrkB Kinase Activity is Critical for Recovery of Respiratory Function After Cervical Spinal Cord Hemisection Experimental Neurology. Nov, 2014 | Pubmed ID: 24910201 Convergence of Pattern Generator Outputs on a Common Mechanism of Diaphragm Motor Unit Recruitment Progress in Brain Research. 2014 | Pubmed ID: 24746055 Cigarette Smoke-induced Mitochondrial Fragmentation and Dysfunction in Human Airway Smooth Muscle American Journal of Physiology. Lung Cellular and Molecular Physiology. May, 2014 | Pubmed ID: 24610934 Physiology's Impact: Stop Ignoring the Obvious-sex Matters! Physiology (Bethesda, Md.). Jan, 2014 | Pubmed ID: 24382865 Inflammation, Caveolae and CD38-mediated Calcium Regulation in Human Airway Smooth Muscle Biochimica Et Biophysica Acta. Feb, 2014 | Pubmed ID: 24275509 Mechanical Properties of Respiratory Muscles Comprehensive Physiology. Oct, 2013 | Pubmed ID: 24265238 Rebuttal from Gary C. Sieck and Carlos B. Mantilla The Journal of Physiology. Nov, 2013 | Pubmed ID: 24187076 CrossTalk Opposing View: The Diaphragm Muscle Does Not Atrophy As a Result of Inactivity The Journal of Physiology. Nov, 2013 | Pubmed ID: 24187074 Impact of Diaphragm Muscle Fiber Atrophy on Neuromotor Control Respiratory Physiology & Neurobiology. Nov, 2013 | Pubmed ID: 23831121 Diaphragm Muscle Sarcopenia in Aging Mice Experimental Gerontology. Sep, 2013 | Pubmed ID: 23792145 Targeted Delivery of TrkB Receptor to Phrenic Motoneurons Enhances Functional Recovery of Rhythmic Phrenic Activity After Cervical Spinal Hemisection PloS One. 2013 | Pubmed ID: 23724091 Effects of the Inflammatory Cytokines TNF-α and IL-13 on Stromal Interaction Molecule-1 Aggregation in Human Airway Smooth Muscle Intracellular Ca(2+) Regulation American Journal of Respiratory Cell and Molecular Biology. Oct, 2013 | Pubmed ID: 23713409 Novel Method for Transdiaphragmatic Pressure Measurements in Mice Respiratory Physiology & Neurobiology. Aug, 2013 | Pubmed ID: 23632282 Motoneuron BDNF/TrkB Signaling Enhances Functional Recovery After Cervical Spinal Cord Injury Experimental Neurology. Sep, 2013 | Pubmed ID: 23583688 Neuromotor Control in Chronic Obstructive Pulmonary Disease Journal of Applied Physiology (Bethesda, Md. : 1985). May, 2013 | Pubmed ID: 23329816 A Novel and Selective Poly (ADP-ribose) Polymerase Inhibitor Ameliorates Chemotherapy-induced Painful Neuropathy PloS One. 2013 | Pubmed ID: 23326593 Prolonged C2 Spinal Hemisection-induced Inactivity Reduces Diaphragm Muscle Specific Force with Modest, Selective Atrophy of Type IIx And/or IIb Fibers Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2013 | Pubmed ID: 23195635 Non-stationarity and Power Spectral Shifts in EMG Activity Reflect Motor Unit Recruitment in Rat Diaphragm Muscle Respiratory Physiology & Neurobiology. Jan, 2013 | Pubmed ID: 22986086 Respiratory Muscle Plasticity Comprehensive Physiology. Apr, 2012 | Pubmed ID: 23798306 Caveolin-1 Knockout Mice Exhibit Airway Hyperreactivity American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2012 | Pubmed ID: 22923642 Systems Biology of Skeletal Muscle: Fiber Type As an Organizing Principle Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 2012 | Pubmed ID: 22811254 Inflammation Alters Regional Mitochondrial Ca²+ in Human Airway Smooth Muscle Cells American Journal of Physiology. Cell Physiology. Aug, 2012 | Pubmed ID: 22673614 Reduced Ribosomal Protein S6 Phosphorylation After Progressive Resistance Exercise in Growing Adolescent Rats Journal of Strength and Conditioning Research. Jun, 2012 | Pubmed ID: 22614147 Effects of Milrinone on Left Ventricular Cardiac Function During Cooling in an Intact Animal Model Cryobiology. Aug, 2012 | Pubmed ID: 22465655 Mechanisms of Intrinsic Force in Small Human Airways Respiratory Physiology & Neurobiology. Apr, 2012 | Pubmed ID: 22322114 Caveolin-1 Regulation of Store-operated Ca(2+) Influx in Human Airway Smooth Muscle The European Respiratory Journal. Aug, 2012 | Pubmed ID: 22241747 Phrenic Motoneuron Expression of Serotonergic and Glutamatergic Receptors Following Upper Cervical Spinal Cord Injury Experimental Neurology. Mar, 2012 | Pubmed ID: 22227062 Structure-activity Relationships in Rodent Diaphragm Muscle Fibers Vs. Neuromuscular Junctions Respiratory Physiology & Neurobiology. Jan, 2012 | Pubmed ID: 22063925 Inhaled Carbon Monoxide Attenuates Myocardial Inflammatory Cytokine Expression in a Rat Model of Cardiopulmonary Bypass The Journal of Extra-corporeal Technology. Sep, 2011 | Pubmed ID: 22164452 The Physiologic Responses to Epinephrine During Cooling and After Rewarming in Vivo Critical Care (London, England). 2011 | Pubmed ID: 21943089 Sodium-calcium Exchange in Intracellular Calcium Handling of Human Airway Smooth Muscle PloS One. 2011 | Pubmed ID: 21858195 Phrenic Motor Unit Recruitment During Ventilatory and Non-ventilatory Behaviors Respiratory Physiology & Neurobiology. Oct, 2011 | Pubmed ID: 21763470 Myosin Filament Polymerization and Depolymerization in a Model of Partial Length Adaptation in Airway Smooth Muscle Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2011 | Pubmed ID: 21659490 Chronic Assessment of Diaphragm Muscle EMG Activity Across Motor Behaviors Respiratory Physiology & Neurobiology. Jul, 2011 | Pubmed ID: 21414423 Intracellular Signaling Pathways Regulating Net Protein Balance Following Diaphragm Muscle Denervation American Journal of Physiology. Cell Physiology. Feb, 2011 | Pubmed ID: 21084642 Neuregulin-1 at Synapses on Phrenic Motoneurons The Journal of Comparative Neurology. Oct, 2010 | Pubmed ID: 20878784 Diaphragm Motor Unit Recruitment in Rats Respiratory Physiology & Neurobiology. Aug, 2010 | Pubmed ID: 20620243 Distribution of Major Basic Protein on Human Airway Following in Vitro Eosinophil Incubation Mediators of Inflammation. 2010 | Pubmed ID: 20339471 Impairment of Diaphragm Muscle Force and Neuromuscular Transmission After Normothermic Cardiopulmonary Bypass: Effect of Low-dose Inhaled CO American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Mar, 2010 | Pubmed ID: 20089713 Mechanisms Underlying Hypothermia-induced Cardiac Contractile Dysfunction American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2010 | Pubmed ID: 20023122 Correlation of Respiratory Activity of Contralateral Diaphragm Muscles for Evaluation of Recovery Following Hemiparesis Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference. 2009 | Pubmed ID: 19965125 Asthma and Sarcoplasmic Reticulum Ca2+ Reuptake in Airway Smooth Muscle American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2009 | Pubmed ID: 19783641 Characterization of Secophalloidin-induced Force Loss in Cardiac Myofibrils Journal of Muscle Research and Cell Motility. 2009 | Pubmed ID: 19763850 Neuromuscular Adaptations to Respiratory Muscle Inactivity Respiratory Physiology & Neurobiology. Nov, 2009 | Pubmed ID: 19744580 Role of Neurotrophins in Recovery of Phrenic Motor Function Following Spinal Cord Injury Respiratory Physiology & Neurobiology. Nov, 2009 | Pubmed ID: 19703592 Novel Method for Physiological Recruitment of Diaphragm Motor Units After Upper Cervical Spinal Cord Injury Journal of Applied Physiology (Bethesda, Md. : 1985). Sep, 2009 | Pubmed ID: 19628723 Retrograde Labeling of Phrenic Motoneurons by Intrapleural Injection Journal of Neuroscience Methods. Sep, 2009 | Pubmed ID: 19559048 The Effect of Denervation on Protein Synthesis and Degradation in Adult Rat Diaphragm Muscle Journal of Applied Physiology (Bethesda, Md. : 1985). Aug, 2009 | Pubmed ID: 19520837 Wireless Instantaneous Neurotransmitter Concentration System-based Amperometric Detection of Dopamine, Adenosine, and Glutamate for Intraoperative Neurochemical Monitoring Journal of Neurosurgery. Oct, 2009 | Pubmed ID: 19425899 Effect of Proinflammatory Cytokines on Regulation of Sarcoplasmic Reticulum Ca2+ Reuptake in Human Airway Smooth Muscle American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2009 | Pubmed ID: 19395670 Characterization of Primary Cilia in Human Airway Smooth Muscle Cells Chest. Aug, 2009 | Pubmed ID: 19318679 Trophic Factor Expression in Phrenic Motor Neurons Respiratory Physiology & Neurobiology. Dec, 2008 | Pubmed ID: 18708170 Key Aspects of Phrenic Motoneuron and Diaphragm Muscle Development During the Perinatal Period Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2008 | Pubmed ID: 18403452 Regulation of Store-operated Ca2+ Entry by CD38 in Human Airway Smooth Muscle American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2008 | Pubmed ID: 18178673 Role of Transient Receptor Potential C3 in TNF-alpha-enhanced Calcium Influx in Human Airway Myocytes American Journal of Respiratory Cell and Molecular Biology. Aug, 2006 | Pubmed ID: 16574942 Diaphragm Dysfunction in Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. Jul, 2005 | Pubmed ID: 15849324 Volatile Anaesthetic Effects on Na+-Ca2+ Exchange in Rat Cardiac Myocytes The Journal of Physiology. Apr, 2001 | Pubmed ID: 11283227 F-actin Stabilization Increases Tension Cost During Contraction of Permeabilized Airway Smooth Muscle in Dogs The Journal of Physiology. Sep, 1999 | Pubmed ID: 10457068 Cervical Dorsal Rhizotomy Enhances Serotonergic Innervation of Phrenic Motoneurons and Serotonin-dependent Long-term Facilitation of Respiratory Motor Output in Rats The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 1998 | Pubmed ID: 9763486 Assessing Functional Recovery of Eupneic Diaphragm Activity Following Unilateral Cervical Spinal Cord Injury in Rats Obaid U. Khurram1, Matthew J. Fogarty1, Wen-Zhi Zhan1, Carlos B. Mantilla1,2, Gary C. Sieck1,2 1Department of Physiology and Biomedical Engineering, Mayo Clinic, 2Department of Anesthesiology and Perioperative Medicine, Mayo Clinic JoVE 66828 Neurociência
Assessing Functional Recovery of Eupneic Diaphragm Activity Following Unilateral Cervical Spinal Cord Injury in Rats Obaid U. Khurram1, Matthew J. Fogarty1, Wen-Zhi Zhan1, Carlos B. Mantilla1,2, Gary C. Sieck1,2 1Department of Physiology and Biomedical Engineering, Mayo Clinic, 2Department of Anesthesiology and Perioperative Medicine, Mayo Clinic JoVE 66828 Neurociência
