Penn State Milton S. Hershey Medical Center 1 article published in JoVE Medicine Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection Jay D. Raman1, Kathleen K. Lehman1, Kalyan Dewan2, Girish Kirimanjeswara2 1Division of Urology, Penn State Milton S. Hershey Medical Center, 2Department of Veterinary and Biomedical Sciences, Penn State University Here, we present a protocol for use at the time of transrectal ultrasound guided prostate needle biopsy (TRUS PNB) that is a simple and cost-effective means to reduce infections following the procedure.