University of Toronto, Scarborough View Institution's Website 4 articles published in JoVE Medicine Development of a Unilaterally-lesioned 6-OHDA Mouse Model of Parkinson's Disease Sherri L. Thiele1, Ruth Warre1, Joanne E. Nash1 1Centre for Neurobiology of Stress, Dept Biological Sciences, University of Toronto at Scarborough A protocol for performing unilateral 6-OHDA lesions of the medial forebrain bundle in mice is described. This method has a low mortality rate (13.3 %) with 89% of the surviving animals showing >95% loss of striatal dopamine and 90.63±-4.02 % ipsiversive rotational bias towards the side of the lesion. Neuroscience Investigating Social Cognition in Infants and Adults Using Dense Array Electroencephalography (dEEG) Adekemi J. Akano1, David W. Haley1, Joanna Dudek1 1Department of Psychology, University Toronto Scarborough Dense array electroencephalography is being used increasingly to study social cognitive functions in infants and adults. Here we present an established methodology that represents a significant improvement on conventional methodologies for studying EEG in infants and adults. Neuroscience A Procedure for Studying the Footshock-Induced Reinstatement of Cocaine Seeking in Laboratory Rats David A. Kupferschmidt1, Zenya J. Brown1, Suzanne Erb1 1Psychology, University of Toronto Scarborough Animal models of relapse, known as reinstatement procedures, have been used extensively to study the role of stress in relapse to drug seeking. Here, we report on a method for inducing the reinstatement of cocaine seeking in laboratory rats via acute exposures to mild, intermittent electric footshock. Biology Exploring Cognitive Functions in Babies, Children & Adults with Near Infrared Spectroscopy Mark H. Shalinsky1, Iouila Kovelman1, Melody S. Berens2, Laura-Ann Petitto2 1Department of Psychology, University of Michigan, Ann Arbor, 2Department of Psychology, University of Toronto Scarborough Here we describe a data collection and data analysis method for functional Near Infrared Spectroscopy (fNIRS), a novel non-invasive brain imaging system used in cognitive neuroscience, particularly in studying child brain development. This method provides a universal standard of data acquisition and analysis vital to data interpretation and scientific discovery.