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Plating Primary Human Hepatocytes for Setting Up the All-Human 2D+ Hepatic Culture System (Video) | JoVE
 
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Plating Primary Human Hepatocytes for Setting Up the All-Human 2D+ Hepatic Culture System (Video) | JoVE

A Physiologically-Relevant All-Human 2D+ Hepatic System for Drug Discovery

Article DOI: 10.3791/200769-v • 03:30 min • October 20th, 2023
October 20th, 2023 •
1, 2, 3, 4, 1, 1
1Institute of Regenerative Medicine, LifeNet Health, 2Biologics Division, LifeNet Health, 3LifeSciences Division, LifeNet Health, 4Research and Development, LifeSciences, LifeNet Health

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All-human hepatisk kultur system lægemiddeludvikling primære humane hepatocytter farmakologiske undersøgelser toksikologiske undersøgelser in vitro modelplatforme fænotypisk stabilitet eksperimentel reproducerbarhed optøning plettering vedligeholdelse todimensionelle kulturteknikker tredimensionelle systemer vedhæftning blodpladeevne såningstæthed funktionalitet langsigtet kultur hepatocytkolonier hepatisk-specifik markør levedygtighed arkitektonisk integritet albuminniveauer urinstofniveauer Farmakologiske anvendelser toksikologiske anvendelser
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