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Biochemistry

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JoVE Journal Biochemistry
Using Smart Leginon Autoscreen for CryoEM Grid Screening
 

Using Smart Leginon Autoscreen for CryoEM Grid Screening

Accelerating Macromolecular Structural Analysis Using Smart Leginon Autoscreen

Article DOI: 10.3791/201401-v • 06:13 min • December 1st, 2023
December 1st, 2023 •
1,2, *1, *1, *1, 1, 1, 1
1Simons Electron Microscopy Center, New York Structural Biology Center, 2Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology
* These authors contributed equally

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Keywords: Cryo-electron Microscopy Screening Automation Smart Leginon Data Collection Data Analysis Machine Learning Particle Picking 3D Flexibility Analysis Model Building Grid Screening Sample Preparation CryoEM Workflow Structural Biology Macromolecular Protein Complexes Grid Optimization
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