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Neuroscience

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JoVE Journal Neuroscience
Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
 

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Article DOI: 10.3791/2330-v • 14:57 min • March 23rd, 2011
March 23rd, 2011 •
1, 2, 2,3
1Graduate Center for Gerontology, University of Kentucky College of Public Health, 2Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, 3Sanders-Brown Center on Aging, University of Kentucky College of Medicine

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This article outlines procedures for preparing hippocampal slices from rats and transgenic mice for the study of synaptic alterations associated with brain aging and age-related neurodegenerative diseases, such as Alzheimer’s disease.

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Acute Hippocampal Slices Rats Transgenic Mice Synaptic Alterations Aging Amyloid Pathology Synaptic Function Plasticity Electrophysiological Techniques Cognitive Impairments Synaptic Plasticity Mechanisms Long-term Potentiation Long-term Depression Nootropic Compounds Brain Aging Alzheimer's Disease (AD) Aged Rats AD Model Mice
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