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Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects
 

Peptides from Phage Display Library Modulate Gene Expression in Mesenchymal Cells and Potentiate Osteogenesis in Unicortical Bone Defects

Article DOI: 10.3791/2362-v • 07:53 min • December 10th, 2010
December 10th, 2010 •
1, 1, 1, 2, 3, 1, 1
1Orthopaedics Research, University of Virginia, 2Biological Sciences, University of Delaware, 3Orthopaedic Surgery, University of Virginia

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A phage display library was used to identify peptide sequences that target bone. The objective was to investigate the effect of these peptides on mesenchymal cell differentiation and to determine their effect on bone regeneration.

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Peptides Phage Display Library Gene Expression Mesenchymal Cells Osteogenesis Unicortical Bone Defects Bone Formation Collagen Matrix Alkaline Phosphatase Activity Nodule Formation Runx2 Osterix Bone Sialoprotein Osteocalcin Collagen Sponge Repair Of Bone Defects In Vitro Differentiation In Vivo Delivery
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