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JoVE Journal Bioengineering
Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves
 

Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves

Article DOI: 10.3791/3316-v • 07:12 min • August 23rd, 2011
August 23rd, 2011 •
1, 1, 1
1Department of Agricultural and Biological Engineering, Mississippi State University

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A cyclic pressure bioreactor capable of subjecting heart valve tissue to physiological and pathological pressure conditions has been designed. A LabVIEW program allows users to control pressure magnitude, amplitude and frequency. This device can be used to study the mechanobiology of heart valve tissue or isolated cells.

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Cyclic Pressure Bioreactor Ex Vivo Study Aortic Heart Valves Aortic Valve Unidirectional Blood Flow Backflow Prevention Interstitial Cells Extracellular Matrix (ECM) Endothelial Cell Monolayer Mechanical Stress Calcific Lesions Aortic Valve Disease High Blood Pressure Valve Replacement Bioprosthetic Valve Mechanical Valve Valve Biology Physical Stresses Mechanobiology Native Heart Valves Engineered Heart Valves Pulsatile Bioreactors Cartilage Study Bone Study Bladder Study
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