Waiting
Processando Login

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Bioengineering / On-Chip Endothelial Inflammatory Phenotyping
JoVE Journal
Bioengineering
Author Produced

É necessário ter uma assinatura JoVE para assistir este Faça login ou comece sua avaliação gratuita.

JoVE Journal Bioengineering
On-Chip Endothelial Inflammatory Phenotyping
 
Click here for the English version

On-Chip Endothelial Inflammatory Phenotyping

Article DOI: 10.3791/4169-v • 12:44 min • July 21st, 2012
July 21st, 2012 •
*1, *1, 1, 1, 1, 1, 1
1Department of Biomedical Engineering, University of California, Davis
* These authors contributed equally

Capítulos

Resumo
Automatic Translation

Please note that all translations are automatically generated.

Click here for the English version.

Microfluidic flow chambers etched by photolithography and fabricated from PDMS are applied to probe functional outcomes associated with EC dysfunction and inflammation. In a representative experiment, the ability of differential shear stress to modulate monocytic cell adhesion to cytokine activated EC monolayers is demonstrated.

Tags

On-Chip Endothelial Inflammatory Phenotyping Atherogenesis Metabolic Abnormalities Systemic Inflammation Endothelial Dysfunction Functional Changes In Endothelium Risk Assessment Therapeutic Strategy Regulation Of Inflammation Local Hemodynamics Non-random Spatial Distribution Of Atherosclerosis Lab-on-a-chip Quantitatively Assay Metabolic Perturbation Inflammatory Events In Endothelial Cells Monocytes Flow Conditions Soft Lithography Microfabricate Vascular Mimetic Microfluidic Chambers (VMMC) Cultured EC Monolayers Imaging Inflammatory Events Shear Field Cytokine-induced Inflammation Lipid-induced Inflammation RAGE-induced Inflammation Human Aortic EC (HAEC) Monocytic Cell Rolling And Arrest TNF-alpha
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter