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Capítulos
- 00:05Título
- 02:43Preprocessing: Preparing Input Files for Bayesian Change-point (BCP) Analysis & ChIP Read Densities for Detection of Enriched Islands in Diffuse Data
- 04:48Estimating the Posterior Mean Read Density of Each Block using BCMIX Approximation
- 06:24Post-processing Posterior Means of Diffuse Read Profiles
- 07:06Results: Comparison of BCP and SICER in Analysis of Histone Modification Data
- 11:47Conclusion
Onze Bayesiaanse Change Point (BCP) algoritme is gebaseerd op state-of-the-art ontwikkelingen in het modelleren change-punten via Hidden Markov Models en past deze toe op chromatine immunoprecipitatie sequencing (ChIPseq) data-analyse. BCP presteert goed in zowel brede en punctata data types, maar blinkt uit in nauwkeurig identificeren van robuuste, reproduceerbare eilanden van diffuse histon verrijking.
Tags
Bayesian Change-point AlgorithmGenome-wide AnalysisChIPseq Data TypesProtein-DNA InteractionsRead Density ProfilesPeaksTranscription FactorsHistone ModificationsStatistical ModelsHidden Markov Models (HMMs)Ad Hoc ParametersResolutionUsabilityParameter Estimation ProceduresFinite State Classifications
