02:43Preprocessing: Preparing Input Files for Bayesian Change-point (BCP) Analysis & ChIP Read Densities for Detection of Enriched Islands in Diffuse Data
04:48Estimating the Posterior Mean Read Density of Each Block using BCMIX Approximation
06:24Post-processing Posterior Means of Diffuse Read Profiles
07:06Results: Comparison of BCP and SICER in Analysis of Histone Modification Data
Onze Bayesiaanse Change Point (BCP) algoritme is gebaseerd op state-of-the-art ontwikkelingen in het modelleren change-punten via Hidden Markov Models en past deze toe op chromatine immunoprecipitatie sequencing (ChIPseq) data-analyse. BCP presteert goed in zowel brede en punctata data types, maar blinkt uit in nauwkeurig identificeren van robuuste, reproduceerbare eilanden van diffuse histon verrijking.