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可重放截瘫胸主动脉阻断脊髓缺血再灌注的小鼠模型

JoVE Journal
Medicina

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JoVE Journal Medicina

Reproducable Paraplegia by Thoracic Aortic Occlusion in a Murine Model of Spinal Cord Ischemia-reperfusion

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可重放截瘫胸主动脉阻断脊髓缺血再灌注的小鼠模型

DOI:

10.3791/50910-v

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05:59 min

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March 03, 2014

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Marshall T. Bell, T. Brett Reece, Phillip D. Smith, Joshua Mares, Michael J. Weyant, Joseph C. Cleveland Jr., Kirsten A. Freeman, David A. Fullerton, Ferenc Puskas

¹Department of Surgery, Division of Cardiothoracic Surgery,University of Colorado, ²Department of Anesthesiology,University of Colorado

Capítulos

00:05Título
02:06Rectal Probe Doppler Placement
02:54Dissection of Aortic Arch/Subclavian Artery
04:59Representative Thoracic Aortic Occlusion-induced Paraplegia Results
05:38Conclusion

Summary

Tadução automática

脊髓缺血再灌注损伤的机理认识的缺乏阻碍了进一步的附属物，以防止截瘫以下高风险的主动脉操作。因此，动物模型的开发是必不可少的。这个手稿展示了可重复的下肢瘫痪继小鼠模型主动脉闭塞。

Tags

Keywords: Spinal Cord Ischemia-reperfusion Thoracic Aortic Occlusion Lower Extremity Paralysis Murine Model Reproducible Paraplegia Functional Analysis Moderate Ischemia Prolonged Ischemia Survival Rates

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