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Immunology and Infection

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JoVE Journal Immunology and Infection
The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice
 

The Utilization of Oropharyngeal Intratracheal PAMP Administration and Bronchoalveolar Lavage to Evaluate the Host Immune Response in Mice

Article DOI: 10.3791/51391-v • 12:27 min • April 2nd, 2014
April 2nd, 2014 •
1
1Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University

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The host immune response to pathogen infection is a tightly regulated process. Utilizing a lipopolysaccharide lung exposure model in mice, it is possible to conduct high resolution evaluations of the complex mechanisms associated with disease pathogenesis.

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Keywords: Oropharyngeal Intratracheal Administration Bronchoalveolar Lavage Host Immune Response Lipopolysaccharide PAMP Acute Lung Inflammation Innate Immunity Host-pathogen Interaction Mouse Model
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