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Controlling Parkinson’s Disease With Adaptive Deep Brain Stimulation
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JoVE Journal Medicina
Controlling Parkinson’s Disease With Adaptive Deep Brain Stimulation

Controlling Parkinson’s Disease With Adaptive Deep Brain Stimulation

DOI:
10.3791/51403-v

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11:12 min

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July 16, 2014

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, , , , , , ,
1Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital,University of Oxford, 2Sobell Department of Motor Neuroscience & Movement Disorders, Unit of Functional Neurosurgery,UCL Institute of Neurology

Capítulos

  • 00:05Título
  • 02:17Consent and Biomarker Identification
  • 04:25Connection of Patient to aDBS Setup
  • 05:33Testing of Conventional Continuous Stimulation
  • 06:22Testing of Threshold with On / Off Switching and Trigger Setting
  • 08:12Testing of Patient Across Different Stimulation Conditions
  • 09:38Results: Clinical Improvements with aDBS
  • 10:36Conclusion

Summary

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Adaptive deep brain stimulation (aDBS) is effective for Parkinson’s disease, improving symptoms and reducing power consumption compared to conventional deep brain stimulation (cDBS). In aDBS we track a local field potential biomarker (beta oscillatory amplitude) in real time and use this to control the timing of stimulation.

Tags

Parkinson’s DiseaseAdaptive Deep Brain StimulationADBSSubthalamic NucleusBeta AmplitudeReal-time OptimizationMotor FunctionUPDRSPower ConsumptionChronic Stimulation

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