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Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions
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JoVE Journal Medicina
Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

Slow-release Drug Delivery through Elvax 40W to the Rat Retina: Implications for the Treatment of Chronic Conditions

DOI:
10.3791/51563-v

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07:49 min

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September 17, 2014

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, , , , ,
1Biotechnology and Applied Clinical Sciences Department,University of L’Aquila, 2ARC Centre of Excellence in Vision Science, 3John Curtin School of Medical Research,Australian National University, 4ANU Medical School,Australian National University

Capítulos

  • 00:05Título
  • 01:27Preparing Reagents
  • 01:59Loading the Drug-resin Complex
  • 03:51Preparing the Drug-resin Complex for Implantation
  • 04:39Implanting the Drug-resin Complex
  • 06:21Results: Retinal Response after APB-complex Implantation
  • 07:10Conclusion

Summary

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This paper details how Elvax 40W can be used as a slow-release method for drug delivery to the adult rat retina. The protocol for preparing, loading, and delivering the drug-resin complex to the eye is described.

Tags

Elvax 40WSlow-release Drug DeliveryRat RetinaChronic Retinal Disease2-amino-4-phosphonobutyrate (APB)Glutamate AnalogueVitreous CavityIntraocular InjectionsRetinal ResponseCopolymer Resin

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