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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
 

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Article DOI: 10.3791/53196-v • 07:36 min • November 20th, 2015
November 20th, 2015 •
1,2, 3, 1, 3, 3,4
1Department of Pediatrics, University of New Mexico, 2Department of Neurosciences, University of New Mexico, 3Department of Neurosurgery, Boston Children's Hospital, 4Department of Neurology, Harvard Medical School

Capítulos

Resumo
Automatic Translation

Encephalopathy of prematurity encompasses the central nervous system abnormalities associated with injury from preterm birth. This report describes a clinically relevant rat model of in utero transient systemic hypoxia-ischemia and intra-amniotic lipopolysaccharide administration (LPS) that mimics chorioamnionitis, and the related impact of infectious stimuli and placental underperfusion on CNS development.

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Keywords: Encephalopathy Of Prematurity Prenatal Hypoxia-ischemia Intra-amniotic Lipopolysaccharide Rat Model Central Nervous System Abnormalities Preterm Birth Placental Underperfusion Chorioamnionitis Inflammation White Matter Injury Functional Deficits
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