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Murine Left Anterior Descending (LAD) Coronary Artery Ligation
 

Murine Left Anterior Descending (LAD) Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction

Article DOI: 10.3791/55353-v • 10:39 min • April 2nd, 2017
April 2nd, 2017 •
*1, *1, 1, 1, 1, 1
1Cardiothoracic Surgery Division, Rhode Island Hospital, Brown University Warren Alpert Medical School
* These authors contributed equally

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We provide a reliable method for left anterior descending artery (LAD) ligation in a mouse model. This method is comparatively less invasive than other methods, involving endotracheal intubation, a left-sided thoracotomy approach, and thoracentesis. This method can be used as a model for both acute and chronic myocardial infarction (MI).

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Keywords: Murine Left Anterior Descending (LAD) Coronary Artery Ligation Myocardial Infarction Mouse Model Cardiovascular Research Endotracheal Intubation Sedation Oropharynx Tracheal Intubation Ventilator Thoracotomy Coronary Artery Ligation
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