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1The Ph.D. Program for Neural Regenerative Medicine, College of Medical Science and Technology,Taipei Medical University and National Health Research, 2Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology,Taipei Medical University, 3TMU research center for Neurotrauma and Neuroregeneration, College of Medical Science and Technology,Taipei Medical University
Capítulos
- 00:05Título
- 01:21Preparation of Micro-osmotic Pump Infusion Systems
- 02:41Intracerebral Ventricular Surgery – Implantation of the Micro-osmotic Pump
- 04:15Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT)
- 06:04Results: Glucose Metabolism and Insulin Signal Activation
- 07:27Conclusion
Questo protocollo studia il ruolo del ligando di chemochina (motivo C-C) 5 (CCL5) nell'ipotalamo fornendo un antagonista, MetCCL5, nel cervello del mouse utilizzando un sistema di infusione cervello pompa micro-osmotica. Questa inibizione transitoria di CCL5 attività interrotta ipotalamico insulina segnalazione, che conduce ad intolleranza al glucosio e la sensibilità periferica dell'insulina sistemica.
