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Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
 

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Article DOI: 10.3791/56464-v • 11:57 min • November 26th, 2017
November 26th, 2017 •
1,2, 1, 1,2, 1, 1, 1
1Protein Aggregation and Aging, German Center for Neurodegenerative Diseases (DZNE), 2Graduate School of Cellular and Molecular Neuroscience, German Center for Neurodegenerative Diseases (DZNE)

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The goal of the method presented here is to explore protein aggregation during normal aging in the model organism C. elegans. The protocol represents a powerful tool to study the highly insoluble large aggregates that form with age and to determine how changes in proteostasis impact protein aggregation.

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Protein Aggregation Inherent Protein Insolubility Caenorhabditis Elegans Age-related Changes Targeted Gene Knockdown Proteostasis Aging Marker Protein Aggregation In Model Organisms S Basal Media Carbenicillin IPTG L1 Stage Worms Centrifugation Worm Collection
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