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Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse
 

Posterior Semicircular Canal Approach for Inner Ear Gene Delivery in Neonatal Mouse

Article DOI: 10.3791/56648-v • 03:52 min • March 2nd, 2018
March 2nd, 2018 •
1, 1,2
1National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 2Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine

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Resumo
Automatic Translation

In this study, we describe the posterior semicircular canal approach as a reliable method for inner ear gene delivery in neonatal mice. We show that gene delivery through the posterior semicircular canal is able to perfuse the entire inner ear.

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Keywords: Posterior Semicircular Canal Inner Ear Gene Delivery Neonatal Mouse AAV8-whirlin Gene Therapy Hair Cell Transduction Stereocilia Elongation Surgical Dissection Micro-injection
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