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Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice
JoVE Journal
Biologia
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JoVE Journal Biologia
Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice
DOI:

08:55 min

July 04, 2018

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Capítulos

  • 00:04Título
  • 00:49Pre-test Assessment and Management
  • 01:59Assessment and Management During the Test
  • 06:55Results: Representative Nasal PD Tracings
  • 08:03Conclusion

Summary

Tadução automática

Here, we present a protocol to measure nasal potential difference in mice. The test quantifies the function of transmembrane ion transporters such as the cystic fibrosis transmembrane conductance regulator and the epithelial sodium channel. It is valuable to evaluate the efficacy of novel therapies for cystic fibrosis.

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